SELANK

Certain peptides, like Selank and those derived from milk or plants, have shown potential in modulating brain activity related to anxiety and stress, influencing neurotransmitters and potentially offering anxiolytic effects. 

Here's a more detailed look:

• Peptide Therapy for Anxiety:

  • Selank: This peptide, a synthetic analog of tuftsin, has been studied for its potential to reduce anxiety and improve cognitive function. 

  • Casein Peptide (CP): Derived from milk, CP has shown anxiety-reducing properties in preclinical and clinical investigations, potentially acting through neurotransmitters like dopamine, serotonin, GABA, and acetylcholine. 

  • Walnut Peptide: Combining walnut peptide with casein peptide has shown antianxiety, antioxidant, neuroprotection, and memory-improving effects in zebrafish. 

  • Whey Peptide: Supplementation with whey peptide rich in β-lactolin improves trait anxiety and subjective stress in healthy adults. 

  • Plant-derived peptides: Some peptides derived from plant proteins, such as soybeans, leaves, and grains, exhibit emotional regulatory functions, including anxiolytic-like and antidepressant-like effects. 

  • Ghrelin: This stomach-derived peptide, known for its orexigenic and adipogenic effects, also contributes to the stress response, anxiety, and depression. 

• Mechanisms of Action:

  • Peptides can influence neurotransmitter levels and brain-derived neurotrophic factor (BDNF), which plays a role in brain plasticity and mood regulation. 

  • Some peptides may exert their effects through interactions with receptors in the gut, potentially impacting the gut-brain axis. 

  • Peptides can modulate GABA receptor activity, which is involved in regulating anxiety. 

• Examples of Peptides and their Potential Effects:

  • Oxytocin: This neuropeptide has been revealed as a profound anxiolytic and antistress factor. 

  • Opioid peptides: Food protein-derived peptides with agonistic effects on opioid receptors have great potential for treating anxiety, hypertension, and stress. 

  • RFRPs (RF-amide-related peptides): These peptides act in regulatory regard to the HPG axis and have been associated with different behaviors in male rats. 

• Research and Studies:

  • Studies have shown that Selank can enhance the effect of diazepam (a benzodiazepine) in reducing anxiety in rats under unpredictable chronic mild stress conditions. 

  • Research is ongoing to explore the potential of various peptides for anxiety management and their mechanisms of action. 

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This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.