LIRAGLUTIDE

Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is used to manage type 2 diabetes and, at a higher dose, for weight loss in adults and children with obesity or overweight with weight-related conditions. 

Here's a more detailed overview:

• Mechanism of Action:

  Liraglutide mimics the effects of the natural incretin hormone GLP-1, which helps regulate blood sugar and appetite. 

• Uses:

  • Type 2 Diabetes: Liraglutide improves blood sugar control in people with type 2 diabetes, often in combination with diet, exercise, and other medications. 

  • Weight Management: At a higher dose, liraglutide (Saxenda) is used to help adults and children (12 years and older) lose weight and maintain weight loss, especially those with obesity or overweight with weight-related problems. 

• Administration:

  Liraglutide is administered as a subcutaneous injection, typically once daily. 

• Brand Names:

  Liraglutide is available under the brand names Victoza (for diabetes) and Saxenda (for weight management). 

• Important Considerations:

  • Not for Type 1 Diabetes: Liraglutide is not used to treat type 1 diabetes or diabetic ketoacidosis. 

  • Cardiovascular Risk: Studies have shown that liraglutide can reduce the risk of cardiovascular events in people with type 2 diabetes and established heart or blood vessel disease. 

  • Thyroid C-Cell Tumors: Liraglutide has been associated with an increased risk of thyroid C-cell tumors in animal studies, but not in human studies. 

  • Contraindications: Liraglutide is contraindicated in individuals with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type II. 

• Side Effects:

  Common side effects include gastrointestinal issues like nausea, vomiting, and diarrhea. 

Liraglutide is a medication that has been shown to be effective in promoting weight loss in individuals with obesity. 

Mechanism of Action: 

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It works by stimulating the release of GLP-1, a hormone that helps to regulate appetite, blood sugar, and metabolism. 

Weight Loss Effects: 

Studies have shown that liraglutide can lead to significant weight loss in individuals with obesity. In clinical trials, participants taking liraglutide lost an average of 5-10% of their body weight over one year. Additionally, a larger proportion of liraglutide users achieved clinically meaningful weight loss (5% or more) compared to those taking placebo. 

Side Effects: 

The most common side effects of liraglutide include nausea, vomiting, diarrhea, and abdominal pain. These side effects usually improve over time as the body adjusts to the medication. 

Conclusion: 

Liraglutide is an effective medication for weight loss in individuals with obesity. It works by stimulating GLP-1 release, which helps to regulate appetite and metabolism. Clinical trials have shown that liraglutide can lead to significant weight loss, with a larger proportion of users achieving clinically meaningful results. However, it is important to note that liraglutide should be used in conjunction with a healthy diet and exercise program for optimal weight loss results. 

• Liraglutide (Saxenda): Uses & Side Effects - Cleveland Clinic

  Side effects that you should report to your care team as soon as possible: - Allergic reactions or angioedema—skin rash, ...

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• Liraglutide (Saxenda): Uses & Side Effects - Cleveland Clinic

  Liraglutide decreases your appetite. It helps promote weight loss or maintain weight loss. A healthcare provider may recommend cha...

  Cleveland Clinic

• Liraglutide (Saxenda): Uses & Side Effects - Cleveland Clinic

  Liraglutide decreases your appetite. It helps promote weight loss or maintain weight loss. A healthcare provider may recommend cha...

  Cleveland Clinic

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This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.

RESEARCH PURPOSE ONLY, NOT FOR HUMAN CONSUMPTION