HEXARELIN

Hexarelin, a synthetic peptide, is a growth hormone secretagogue (GHS) that stimulates the release of growth hormone (GH) and may offer benefits like increased muscle mass, improved recovery, reduced fat storage, and potential anti-aging effects. 

Here's a more detailed overview of hexarelin's potential benefits:

• Muscle Growth and Recovery:

  • Hexarelin stimulates the release of GH, which plays a crucial role in muscle protein synthesis and repair. 

  • Increased GH levels can lead to enhanced muscle growth and improved recovery after workouts or injuries. 

• Fat Loss:

  • GH, stimulated by hexarelin, can promote fat burning and reduce fat storage. 

  • This can contribute to improved body composition and a more toned physique. 

• Anti-Aging Effects:

  • GH is known to play a role in maintaining youthful appearance and vitality. 

  • Hexarelin's ability to stimulate GH release may contribute to improved skin health, energy levels, and overall physical performance. 

• Bone Density Improvement:

  • GH is essential for bone growth and maintenance, and hexarelin can potentially contribute to stronger bones and reduced fracture risk. 

• Cardiovascular Health:

  • Some studies suggest that hexarelin may have positive effects on cardiovascular health, potentially improving cardiac function and reducing inflammation. 

• Enhanced Sleep Quality:

  • Some users report improved sleep quality and reduced daytime fatigue while using hexarelin. 

• Other Potential Benefits:

  • Hexarelin may also boost immune function, improve energy levels, and enhance overall well-being. 

• Mechanism of Action:

  • Hexarelin works by binding to specific receptors in the brain, stimulating the release of GH from the pituitary gland. 

  • It is a synthetic peptide that does not interfere with the body's natural GH production. 

Description – Hexarelin

Hexarelin is a growth hormone (GH) releasing peptide (GHRP) analog comprised of 6 amino acid residues and having a methylated ‘Trp’ terminus in order to enhance structural stability and to prolong residence time in the bloodstream1. Earning it the classification of a GH secretagogue (GHS), Hexarelin has been found to promote the production of GH by binding to the GHS (ghrelin) receptor within the pituitary gland and the hypothalamus2.Hexarelin is reported to be a potent agent for the stimulation of GH production, which has been shown to be a promoter of enhanced muscle strength, increased muscle mass, improved joint health, quickened wound healing3, and damage protection threatened by cardiac dysfunction4. Animal testing has demonstrated that Hexarelin stimulates also significant secretion of IGF-1, PRL, ACTH, and cortisol5, while not to inducing appetite and gastric emptying, which is a property of other GHRP analogs6.

Product Comparison – Hexarelin

The regular administration of endogenous, synthetic GH has the potential to cause a parallel reduction of natural GH production as a result of modulation by somatostatin5, which may run counter to desired research outcomes. Rather than using synthetic GH to substitute production of the naturally occurring agent, it promotes natural GH production alongside normal, systemic production.

Hexarelin and GHRP-6 are noted to have similar capabilities in stimulating sustained GH release, but, as mentioned above, Hexarelin lacks GHRP-6’s appetite inducing properties6.

Research products only, they are not for human consumption.

Synonyms:

Hexarelin Acetate, HEX, Examorelin

Peer-Reviewed Sources:

1. Torsello, A., Luoni, M., Schweiger, F., Grilli, R., Guidi, M., Bresciani, E., … & Locatelli, V. (1998). Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. European journal of pharmacology, 360(2), 123-129.

2. Deghenghi, R., Cananzi, M. M., Torsello, A., Battisti, C., Muller, E. E., & Locatelli, V. (1994). GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life sciences, 54(18), 1321-1328.

3. Acosta, J. B., Vera, D. C., Herrera, D. G. D. B., Nieto, G. E. G., Alba, J. S., Mola, E. L., & Castillo, M. V. (2011). Pharmaceutical Composition Containing GHRP-6 To Prevent And Eliminate Fibrosis And Other Pathological Deposits In Tissues. U.S. Patent Application 13/150,526.

4. Locatelli, V., Rossoni, G., Schweiger, F., Torsello, A., De Gennaro Colonna, V., Bernareggi, M., & Berti, F. (1999). Growth Hormone-Independent Cardioprotective Effects of Hexarelin in the Rat 1. Endocrinology, 140(9), 4024-4031.

5. Arvat, E., Maccario, M., Di Vito, L., Broglio, F., Benso, A., Gottero, C., & Ghigo, E. (2001). Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone 1. The Journal of Clinical Endocrinology & Metabolism, 86(3), 1169-1174.

6. Schmid, D. A., Held, K., Ising, M., Uhr, M., Weikel, J. C., & Steiger, A. (2005). Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology, 30(6), 1187-1192.

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.